^ Co-first, * Corresponding/Senior, Advisee. Also available at Google Scholar and ORCID.

Major Work
Redefining the tumor digital twin through cross-domain manifold mapping.
Yuanning Hu, Wei Zong, Juncheng Wang, Manqi Cai, Jian Zou*
The Innovation Oncology, 1, 100012
Commentary, news

2026

Using machine learning to identify the dynamic evolution patterns of negative emotions in perinatal women: A longitudinal study in southwest China.
Yuan Zhang^, Wenlong Li^, Jian Zou^, Guohui Yang, Xiaoni Zhong*, Biao Xie*
MedComm, 6(8), e70331

2025

Mutual information for detecting multi-class biomarkers when integrating multiple bulk or single-cell transcriptomic studies.
Jian Zou, Zheqi Li, Neil Carleton, Steffi Oesterreich, Adrian V Lee, George C. Tseng*
Bioinformatics, 40(12), btae696

2024

2024

Systems approach for congruence and selection of cancer models towards precision medicine.
Jian Zou, Osama Shah, Yu-Chiao Chiu, Tianzhou Ma, Jennifer M Atkinson, Steffi Oesterreich*, Adrian V. Lee*, George C. Tseng*
PLoS Computational Biology, 20(1), e1011754
online tool

2024

Clinicopathological features and outcomes comparing patients with invasive ductal and lobular breast cancer.
Steffi Oesterreich^, Azadeh Nasrazadani^, Jian Zou^, Neil Carleton, …, George Tseng, Adrian V. Lee, Nicole Williams*, Megan Kruse*
JNCI: Journal of the National Cancer Institute, 114(11), 1511–1522

2022

PRECISION.seq: An R package for benchmarking depth normalization in microRNA sequencing.
Jian Zou^, Yannick Düren^, Li-Xuan Qin*
Frontiers in Genetics, 12

2022

Collaborative Work
p95HER2, a truncated form of the HER2 oncoprotein, drives an immunosuppressive program in HER2+ breast cancer that limits trastuzumab deruxtecan efficacy.
Dong Hu*, Xiaoshuang Lyu, Zheqi Li, …, Jian Zou, George Tseng, Tullia Bruno, Adrian Lee, Steffi Oesterreich, Norman Wolmark, Carmen Allegra, Samuel Jacobs, Linda McAllister-Lucas*, Peter Lucas*
Nature Cancer, 1–12

2025

Comprehensive evaluation and practical guideline of gating methods for high-dimensional cytometry data: manual gating, unsupervised clustering, and auto-gating.
Peng Liu^, Yuchen Pan^, Rick Chang^, Yusi Fang, Xiangning Xue, Jian Zou, Jessica M. Toothaker, Oluwabunmi Olaloye, Eduardo Gonzalez Santiago, Vanessa Mitsialis, Pietro Prescicce, Suhas Kallapur, Scott Snapper, Jia-Jun Liu, George C. Tseng*, Liza Konnikova*, Silvia Liu*
Briefings in Bioinformatics, 26(1), bbae633

2025

Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer.
Fangyuan Chen, Sayali Onkar, Jian Zou, Yujia Li, Haley Arbore, Sai Maley, George Tseng, Peter C Lucas, Tullia C Bruno, Dario AA Vignali, Julia Foldi, Marija Balic, Adrian V. Lee*, Steffi Oesterreich*
npj Precision Oncology, 8(1), 257

2024

Electronic health record–based nudge intervention and axillary surgery in older women with breast cancer: a nonrandomized controlled trial.
Neil Carleton, Thomas R. Radomski, Danyang Li, Jian Zou, …, Steffi Oesterreich, George Tseng, Adrian V. Lee, Priscilla F. McAuliffe*
JAMA Surgery, online July 17, 2024

2024

Of mouse models and humans.
George Tseng*, Tianzhou Ma, Jian Zou
American Scientist, 111(4), 213–214
Invited, non-peer-reviewed article

2023

Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment.
Sayali Onkar, Jian Cui, Jian Zou, Carly Cardello, Anthony R Cillo, Mostofa Rafid Uddin, April Sagan, Marion Joy, Hatice U Osmanbeyoglu, Katherine Pogue-Geile, Priscilla F. McAuliffe, Peter C. Lucas, George C. Tseng, Adrian V Lee, Tullia C Bruno, Steffi Oesterreich*, Dario A.A. Vignali*
Nature Cancer, 1–19

2023

Transcriptomic congruence analysis for evaluating model organisms.
Wei Zong, Tanbin Rahman, Li Zhu, Xiangrui Zeng, Yingjin Zhang, Jian Zou, Song Liu, Zhao Ren, Jingyi Jessica Li, Etienne Sibille, Adrian V. Lee, Steffi Oesterreich, Tianzhou Ma*, George C. Tseng*
Proceedings of the National Academy of Sciences, 120(6), e2202584120
News: Genetic Engineering and Biotechnology News

2023

Outcomes after sentinel lymph node biopsy and radiotherapy in older women with early-stage, estrogen receptor–positive breast cancer.
Neil Carleton, Jian Zou, Yusi Fang, …, George C. Tseng, Oscar C. Marroquin, Adrian V. Lee*, Priscilla F. McAuliffe*
JAMA Network Open, 4(4), e216322

2021

The utility of next-generation sequencing in advanced breast and gynecologic cancers: experience of a large tertiary care women’s hospital.
Terrell E. Jones, Jian Zou, George C. Tseng, Somak Roy, Rohit Bhargava*
American Journal of Clinical Pathology, 156(3), 455–460

2021

Statistical assessment of depth normalization for small RNA sequencing.
Li-Xuan Qin*, Jian Zou, Jiejun Shi, Ann Lee, Aleksandra Mihailovic, Thalia A. Farazi, Thomas Tuschl, Samuel Singer
JCO Clinical Cancer Informatics, 4, 567–582

2020

Recent advances in computer-assisted algorithms for cell subtype identification of cytometry data.
Peng Liu^, Silvia Liu^, Yusi Fang, Xiangning Xue, Jian Zou, George C. Tseng*, Liza Konnikova*
Frontiers in Cell and Developmental Biology, 8, 234

2020